The distribution of deleterious genetic variation in human populations
نویسندگان
چکیده
منابع مشابه
The distribution of deleterious genetic variation in human populations.
Population genetic studies suggest that most amino-acid changing mutations are deleterious. Such mutations are of tremendous interest in human population genetics as they are important for the evolutionary process and may contribute risk to common disease. Genomic studies over the past 5 years have documented differences across populations in the number of heterozygous deleterious genotypes, nu...
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Proportionally more deleterious genetic variation in European than in African populations.
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ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2014
ISSN: 0959-437X
DOI: 10.1016/j.gde.2014.09.005